Isolation and identification of a novel microbial alkaloid.

In the course of screening for unique microbial products with pharmacological activity, we have isolated two metabolites from the fermentation filtrate of an unidentified Streptomyces sp. SCC 2313, which exhibited an affinity for muscarinic receptors. The assay directed separation of the active ingredients provided two compounds1 and 2. Based on physico-chemical characteristics, we have elucidated the structure of both the compounds. While microbial product 1 was found to be a knowncompoundand was identical to pyrindicin1>2), a microbial alkaloid, compound 2, has not previously been reported in the literature. This paper describes the production, isolation, physicochemical properties and structure elucidation of